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Enzymatic activity was defined as the quantity of the enzyme required to catalyze the synthesis of 1 nM of the superoxide radical anion per minute

GoyaMEXueFSampedro-Torres-QuevedoCArnaouteliSRiquelme-DominguezLRomanowskiAet al

doi: 10.3390/ijms20051033 182 GiordanoATommonaroG

Although strategies such as iron chelators (e.g., deferoxamine), antioxidants (e.g., N-acetylcysteine), and GPX4 activation demonstrate neuroprotective potential in animal and cellular models, their safety, tolerability, blood-brain barrier permeability, and ability to modulate disease progression in humans have not been systematically validated