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The incorporation of these technologies is likely to improve cardiovascular medicine and accelerate the change from molecular mechanisms to clinical practice, ultimately realizing the 4P vision of precision medicine: Predictive, Preventive, Personalized, and Participatory

The regioselective BaeyerVilliger oxidation of ketone 174 gave lactone intermediate 175, which could be reduced to chiral compound 176

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The lesion of the tuberoinfundibular pathway resulted in the inhibition of CYP2B, CYP3A and CYP2C6

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