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Krecek, R.C., Lee, E., Lucas, H., Drebot, M.A., Wood, H., Loftis, A., Robertson, L., Dimitrova, K., Makowski, K., Dillon, L., Dewailly, E., Morrison, K., Forde, M., Kelly, P., (2013)

Conversely, at high concentrations, it can oxidize the cysteine (SH) or methionine residues (SCH 3 ), which subsequently leads to the inactivation of enzymes like Calvin cycle, Cu/Zn-SOD, and Fe-SOD by oxidation of their thiol groups [48]

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In conclusion, although many reports previously evidenced the regulation of signaling pathways by GSTs in various in vitro cell systems, we demonstrate for the first time that the invalidation of Gstp1/p2 affects multiple key events of the hepatocyte cell cycle in vivo after PH