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Ufer et al., 2010)

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326 In macrophage, high levels of CD38 induced by LXR agonists reduce NAD + levels and interfere with cytoskeletal rearrangements triggered by invasive bacteria, protecting host macrophages from substantial infection

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These reactions become important when cells lose their ability to remove metals, making it available for reaction and/or when cells lose their ability to maintain their vitamin C in a reduced form