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Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4/NF-kappaB/STAT signaling cascade

Coe and colleagues, while evaluating the effects of flavonoid-rich cocoa for fatigue in relapsing and remitting multiple sclerosis (RRMS), concluded that a flavonoid rich beverage has the potential to improve fatigue and fatigability in patients with RRMS (Coe et al

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This culminates in (1) axo-dendritic pathology coupled to loss of synaptic function, (2) impaired mitochondrial dynamics coupled with altered energy homeostasis, and (3) impaired dopamine metabolism, all of which contribute to further RNS imbalance