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A U-shaped curve occurs when increasing a dose starts providing more benefit but only to a point

Furthermore, direct disruption of key antioxidants, such as superoxide dismutase (SOD) and glutathione (GSH), by acrolein and myeloperoxidase (MPO) may play a key role in ovarian disruption and the worsening oxidative state in those seeking treatment with cyclophosphamide

Photosyth Res 45:165175 Brutigam K, Dietzel L, Kleine T, Strher E, Wormuth D, Dietz K-J, Radke D, Wirtz M, Hell R, Drmann P, Nunes-Nesi A, Schauer N, Fernie AR, Oliver SN, Geigenberger P, Leister D, Pfannschmidt T (2009) Dynamic plastid redox signals integrate gene expression and metabolism to induce distinct metabolic states in photosynthetic acclimation in Arabidopsis