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In Addiction (29 January 2018), researchers carried out a meta-analysis of 61 studies involving 27,647 participants who were randomly assigned to either an intervention group, which received smoking cessation medicines including bupropion, varenicline and nicotine replacement therapy, or to a control group, which did not receive active medicines [1]

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Motivation to quit can come from different sources like wanting to have a surgery and needing to be nicotine-free for it, or having family members who are concerned about your health and about the effects of second-hand smoke

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