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The elevation of superoxide dismutase and glutathione peroxidase levels in the experimental birds fed 1.5% MLM supplemented diet may also be linked to the activities of flavonoid, ferric reducing antioxidant properties and 2-diphenyl-1-picrylhydrazyl hydrate in MLM (Table 1)

The above studies have verified the inhibitory effects of quercetin on Cd-induced oxidative stress and other toxic functions, and further studies have shown that the combined treatment with -tocopherol (AT) and quercetin provided more significant protection against Cd-induced oxidative stress and lipid metabolism compared with quercetin alone, thereby reducing Cd-induced cardiovascular disease [128]

Furthermore, combining different transporter inhibitors enhances therapeutic efficacy, showing the potential for synergistic effects in the treatment of pancreatic cancer [49]

This reduction in NRF2 levels results in decreased transcription of downstream antioxidant proteins, suppression of DNA damage repair pathway initiation, and disruption of G2/M phase arrest following radiation exposure [116]