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This interaction not only antagonizes Kyn-induced AhR activation but also suppresses the expression of indoleamine 2,3-dioxygenase (IDO)1a key enzyme driving Trp catabolism to Kynand subsequent differentiation of Tregs, thereby reversing the immunosuppressive TME (112, 161)

Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial

Liver expressed antimicrobial peptide-2 (LEAP2) is also important in this neuroendocrine system, as it acts as an endogenous GHSR inverse agonist and antagonist [6]