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Pharmaceutics 16 , 1423 (2024)

Munir F, Khazaei S, Calkins PH, Scruggs D, Mizuno H, Ostermann LB, Cuglievan B, Garcia MB, Chen D, Tong Y, Ren Z, Andreeff M , and Nishida Y

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The specific mechanisms include: through multiple virulence factors such as lipopolysaccharide, gingipains, and butyrate, the subgingival biofilm synergistically enhances cellular susceptibility to ferroptosis across three pathways, namely iron metabolism, lipid metabolism, and antioxidant defense, thereby providing continuous fuel for the vicious cycle