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NAD+, on the other hand, is a critical coenzyme involved in DNA repair, energy production, and cellular health

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Its levels decline by 4060% with age, primarily due to increased CD38 activity and the heightened demand for PARP-1 for DNA repair

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In sum, the safety observations support the concept that the IRR, the target of ARA 290, is induced only by injury, inflammation or metabolic stress and is therefore not generally expressed by normal tissues, thus limiting systemic adverse events