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These trials should also prioritize the development of specific biomarkers to monitor treatment responses and assess drug efficacy in clinical settings

Patients with severe AH also have a particularly striking burden of infection

In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

Disorders of the mitochondrial transport chain, excessive generation of reactive species and lipoperoxides, as well as decreases in antioxidant mechanisms have also been observed in diabetes and obesity