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4.1 Betaine in hyperhomocysteinemia The elevated plasma total homocysteine (i.e., hyperhomocysteinemia) is a known risk factor for CVDs (Refsum et al., 1998) and is also associated with some neurological disorders ( 4.2 Betaine in cardiovascular diseases Hyperhomocysteinemia is a risk factor for CVDs (Refsum et al., 1998)

Furthermore, on the PGI-C, most participants reported improvement of their overall narcolepsy disease at EOT

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Down-regulation of TMAO levels by dimethyl-1-butanol (DMB), a TMA formation inhibitor, is able to ameliorate the cognitive deterioration and long-term potentiation (LTP) in APP/PS1 mice and decrease amyloid- (A)1-42, -secretase, and -secretase-cleaved C-terminal fragment (CTF) levels in the hippocampus (Morello et al., 2000)

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