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Neuron 84, 340346

doi: 10.1016/j.nbd.2020.104944 89 Harun-Or-RashidMInmanDM

In vitro tests showed that the mutant form of the protein had no chaperone activity and even enhanced the aggregation of test proteins

A significant pathogenic effect that increases neurotoxicity is the release of more systemic inflammatory mediators into the central nervous system due to damage to the BBB [10]