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Induced pluripotent stem cells (iPSCs) generated by reprogramming human somatic cells have been broadly used since 2008 and afford an efficient model system for disease modeling, toxicity screens, and screening for novel therapeutics because of their genetic relevance to individuals with the disease [12,13,14,15,16]

Conversely, mitigating oxidative stress specifically in HCs (via Gpx4 overexpression) reduced ERK phosphorylation in SCs, likely through EGFR signaling across the SC membrane, leading to GSDMD activation

Kim, B.-H

There is evidence that the depletion of SOD, a mitochondrial free radical scavenger, in connective tissue leads to the acceleration of skin ageing [123]

Our aim was to evaluate A1AT heterozygosity as a risk factor for waitlist mortality, and the potential predictive value of low serum A1AT levels in those with normal phenotype