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In immunocompromised mice given cyclophosphamide, administration of 20 mg/kg and 60 mg/kg of C

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The main drawback of this compound is its teratogenicity, a serious problem since a large proportion of AIH patients are women of child bearing age [129, 132]

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One study denotes that the changes in DNA methylation appear to be dependent upon sex of the fetus and gestational timing of exposure, and that exposure in late gestation resulted in fewer significant variations in DNA methylation of targeted genes [101]

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