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Inactivating mutations of KDM5C, commonly found in patients with ccRCC, alter glycogen metabolism, leading to increased NADPH and GSH levels and thereby inhibiting ferroptosis

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5 mg vial + 2 mL BAC water: Concentration = 2,500 mcg/mL 250 mcg dose = 10 units (0.1 mL) on a 100-unit insulin syringe 500 mcg dose = 20 units (0.2 mL) on a 100-unit insulin syringe Doses per vial: 20 doses at 250 mcg, or 10 doses at 500 mcg Supplies Needed (8-Week Cycle at 250 mcg/day) 3 vials BPC-157 (5 mg each) provides 60 doses, covers 56 days with margin 3 vials bacteriostatic water (30 mL each) 60 insulin syringes (2931 gauge, 100-unit) Alcohol prep pads Administration Injection Technique BPC-157 goes subcutaneous (SubQ)

doi: 10.1038/nm.3145 65 WangZKlipfellEBennettBJKoethRLevisonBSDugarBet al

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