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Considering the extent to which obesity impairs health alone or through expression of one or more of these comorbidities, the need for new molecular pharmaceutic agents is crucial

The initial indication that G0S2 was involved in lipolysis was from studies showing that G0S2 mRNA expression is highest in WAT and BAT, upregulated during adipocyte differentiation (51), and a peroxisome proliferator-activated receptor (PPAR) target gene

They bypass the gut entirely, which is crucial if absorption is impaired

doi: 10.1016/j.biochi.2020.02.015 98 van HarenMJTaigRKuppensJSastre ToranoJMoretEEParsonsRBet al