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Moreover, endothelial cells generate chemokines and adhesion molecules, promote the migration and adhesion of SMCs, aggravate vascular stenosis and plaque instability, promote vascular calcification, promote the precipitation of uric acid crystallization, increase blood viscosity, induce 5-HT release, increase platelet number and induce internal platelet activation

Conclusions Our study is the first to identify the specific role of SIRT2 in reactive astrogliosis and determine the specific pathway and metabolic step catalyzed by the enzyme

These findings suggest that further increases in AUR content do not significantly improve drug loading, possibly due to saturation of the drug delivery framework [34]

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J New Drugs (1963) 3:379