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While this observation supports our data that HHEX controls steroid output, current mouse models do not permit us to directly assess the role of HHEX in adrenal androgen production (DHEA) because the mouse adrenal cortex does not express cytochrome P450 17-hydroxylase/17,20 (CYP17) after birth, an enzyme required for androgen synthesis 81

It works through a satiety pathway that is distinct from, and complementary to, GLP-1, which is why it is widely studied both alone and stacked with GLP-1 agonists

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