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(2020) treated dopaminergic neurons MES23.5 cells with ferric ammonium citrate (FAC) to simulate the iron overload of PD, as FAC can upgrade ferritin levels in cells

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AGEs are ligands of the receptor for advanced glycation end products (RAGE) and induce inflammation by activation of the nuclear factor B (NF-B) pathway in all neural cells ( Elevated MG seems to increase the expression of astrocyte markers (glial fibrillary acidic protein GFAP and S100B) and cytokines in astrocyte culture and in vivo , leading to astrogliosis and neuroinflammation ( Elevated MG and AGEs levels play a key role in protein misfolding and oxidative stress, and are also involved in AD ( in vitro models, MG induced glutamatergic excitotoxicity by promoting glutamate release ( In PD, a predictor event is the low activity of neuronal PPP enzymes (Vicente Miranda et al., 2016)

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