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212 However, high levels of autophagic markers such as microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1 (BECN1) correlate with better patient outcomes, suggesting a potential tumor-suppressive function in certain contexts

Vitamin B12 helps decrease homocysteine levels in the blood which lowers the risk of heart disease and stroke

Apart from activation of Nrf2, SFN was also shown to prevent high-fat diet (HFD)-induced NAFLD in mice by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in liver through AMP-activated protein kinase (AMPK)-autophagy axis when administered with a daily dose of 30 mg/kg for 9 weeks along with HFD (Yang et al., 2016)

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though this is uncommon