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The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity

Intravenous (IV) fluid drips deliver saline solution through a small catheter and tubing directly into the bloodstream

Furthermore, the time to first exacerbation was prolonged in the erdosteine group and this was not influenced by the concomitant use of ICS (Table 1)

Conventionally regarded as a nutritionally non-essential amino acid, the bodys glycine supply is provided by the diet and endogenous synthesis 1,2

138,139,140 In turn, NF-B can induce TNF expression in the context of inflammation, such as lipopolysaccharide (LPS) stimulation