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In summary, in SLE patients, mtROS accumulation and mtDNA release may promote ferroptosis and subsequent release of intracellular antigens and DAMPs, thereby mediating the progression of SLE ( Figure 2 )

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6 Unlike the two other immunosuppressants, FK506 and cyclosporin A, whose immunophilin complexes inhibit calcineurin, the rapamycinFKBP12 complex does not interfere with calcineurin but instead directly binds to and inhibits a protein that was named target of rapamycin (TOR)

24 Another study with high-resolution magnetic resonance imaging of 13 patients who died of COVID-19 showed abnormalities in the brains of 10 patients (76.9%)

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