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COAs include detailed analytical results that researchers can use to verify compound specifications and maintain quality control documentation

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These findings empirically support phenotype-aware dose adjustments to reduce adverse effects in PMs and avoid underdosing in UMs

Gastroenterology 1999, 117: 420-428

Stabilization of HIF1a protein levels in intestinal epithelial cells with the PHD-inhibitor roxadustat or pharmacologic inhibition of RIPK3 with GSK-872 prevented necroptosis of intestinal epithelial cells and decreased the incidence and severity of CIA [1]