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Rotenone shows strong synergistic effect with 2.327 M tamoxifen at 2 nM () for MDA-Doxo 400 (Panel B)

Recent animal studies also demonstrated an increase of low-affinity bound copper in the CNS associated with enhanced oxidative stress following initiation of D-penicillamine therapy in the toxic milk mouse model

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Hariri Z, Yari Z, Hoseini S, Abhari K, Sohrab G

Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms