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The Journal of Nutrition and Neuroscience published a review authored by Choudhary et al that reported a possible link between the consumption of aspartame and neurophysiological symptoms

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They actively disrupt the stoichiometry of photosynthetic proteins, degrade PSII, and change the redox state of the plastoquinone pool, resulting in the excessive production and accumulation of ROS, which eventually triggers a cell death that resembles the effector-triggered HR that limits the growth of pathogens 17,23,24,59,60,61