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Int J Environ Res Public Health.2021;18(13):7209

With the reduction of the oxidative phosphorylation complex substrates (output of citric acid cycle) by glycolysis defect or pyruvate dehydrogenase deficiency may result in disturbances on cellular energy production (Armstrong et al

10.1007/s10238-024-01302-6 257

Unfolded protein responses (UPR) are cornerstones in the homeostatic regulation of organelle function 44 , first described for the endoplasmic reticulum and implicated in the pathogenesis of IBD 45,46