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These active components help reduce abnormal -syn aggregation, block its neurotoxic effects, inhibit the apoptosis of dopaminergic neurons in the substantia nigra, regulate microglial activation, reduce the release of pro-inflammatory factors such as TNF- and IL-1, enhance antioxidant defense systems (e.g., by upregulating the Nrf2/HO-1 pathway) to mitigate oxidative stress damage, and promote neuroregeneration and synaptic repair

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Moreover, use in vulnerable populations, including neonates and young children, requires careful riskbenefit evaluation to prevent GI complications and ensure safe administration (567)

In one investigation, NK cell activity in women having surgery for breast cancer was reduced by over 50% on the first day after surgery (McCulloch 1993)

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