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10.3389/fphar.2021.694607 5 Arias-ChvezD

Antioxidants & Redox Signaling

A possible explanation might be that constitutive RAS pathway activity promotes TFRC (a gene related to iron metabolism) expression while suppressing the expression of iron storage proteins

Similarly, as shown for other viruses it could potentially inhibit coronavirus assembly in the Golgi (27)

This selective activation underlines CHAC1s critical function in maintaining cellular homeostasis and its potential involvement in pathological conditions where ER stress is a significant factor (Mungrue et al., 2009)