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Future studies should test whether NRF2 activation can effectively reduce PC and preserve functional -cells in diabetes

Metabolic dysfunction (and the more severe metabolic syndrome) are exacerbated by modern lifestyle and dietary habits, leading to chronic inflammation and oxidative stress, which further degrade cell functioning

Lastly, studies systematically identifying Mn exposure limits based on age, sex, and exposure duration as well as changes in signaling cascades associated with metal homeostasis and protein aggregation need to be conducted

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