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"The main ingredients that give the sparkly glow effect are silica and mica," says David Kim, MD, a board-certified dermatologist in New York City

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

"My rule of thumb is that anything that can stain a white t-shirt can stain your teeth," adds Samantha Rawdin, DMD

Off-label Uses Though approved primarily for acne treatment, isotretinoin is sometimes used off-label for: Rosacea Hidradenitis suppurativa Seborrheic dermatitis Certain skin cancers (with physician supervision) Using Isotretinoin 5 mg Capsules off-label must always be evaluated and prescribed by a qualified healthcare provider