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Clinically significant fluid retention could theoretically alter the volume of distribution of apixaban, though no study has quantified this effect

Acknowledgements This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Liu, L

In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]

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