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For weight management, specific signs include insufficient weight loss despite continued medication adherence and lifestyle efforts, or failure to achieve clinically meaningful weight reduction within the expected timeframe

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To our best knowledge, this is the first systematic review to address these gaps by synthesizing evidence in CAD patients across mechanistic markers such as oxidative stress, inflammatory mediators, autophagy-related markers and post-PCI myocardial-injury biomarkers together with clinical endpoints such as ventricular arrythmia, mortality and angina

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