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Another study found that Parabacteroides distasonis and Ruminococcus torques were overabundant in ALS mice and appeared to have adverse effects, whereas Akkermansia stood out as beneficial [83]

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With respect to endothelial function, evidence to support the concept that eNOS uncoupling contributes to endothelial dysfunction was obtained by experiments demonstrating that supplementation with BH 4 or the BH 4 precursor sepiapterin was able to improve endothelial dysfunction in patients with hypertension