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Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma

To date, more than 20 different AFs have been identified with moderate to high toxicity effects on the human body ( Figure 1 The laboratory analysis of AFs identified several metabolized AFs derivatives that rarely found in the human body ( Fusarium species should be taken into account because of their potential to outbreak and influence the future food safety and security ( The upcoming GCC and future AFs contamination risks The GCC is becoming a serious concern, and being the future driver of food safety and security ( Studies disclosed that GCC induces the occurrence of plant fungal pathogens by providing appropriate environmental requirements for their growth and development ( The GCC might support the growth and development of APF in crop production sites ( Different strategies have been applied to address the GCC in advanced and developing countries (59)

Dosage adjustments are necessary to prevent the accumulation of vitamins that are metabolized or excreted through these organs, reducing the risk of toxicity

Also, there is an urgent need to evaluate the development of this condition by the golden standard the hyperinsulinemic-euglycemic clamp

Hassan, N