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Molecular dynamics simulations demonstrated that the ALOX15-luteolin complex is stable and flexible

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Photo-oxidation is exacerbated during retinal degeneration and progressive loss of photoreceptors, as the choroid cannot alter the inflow of oxygen supply in response to the changing retinal environment, so the remaining photoreceptors become exposed to a higher oxygen level 22

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Although the TME is generally characterized by high ROS levels, moderate and sustained ROS concentrations are crucial for inducing and maintaining the M2 phenotype through several signaling pathways

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