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Modulation of TNF--converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF- production and facilitates viral entry

10.2967/jnmt.121.262008 161

doi:10.1136/bmjsem-2018-000414 13 Gle A, Trk Y, Aydin BK, Erkoak F, Safal S, Ugurluoglu C

This dose has been extensively studied in combination with semaglutide under the investigational name CagriSema, achieving up to 22.7% weight reduction at 68 weeks in phase 3 trials [4]