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20 As the rapid rise in atmospheric O 2 presented a new challenge for cellular energetics, single-celled life forms were forced to adapt, including giving rise to multicellular life

Recent studies have demonstrated that the depletion of GSH can be obtained acting on the different steps of the GSH cycle, triggering mechanisms able to stimulate, as a final result, cancer cell death

have highlighted the crucial regulatory roles of the NRF2 and nuclear factor-kappa B (NF-B) pathways in the oxidative balance homeostasis of mitohormesis 100

ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)

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