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Description

The downregulation of SIRT1 diminishes the inhibitory effect of vitamin K-2 (VK2) on ferroptosis in BMSCs exposed to high glucose, consequently contributing to bone loss ( 2.4 The relationship between ferroptosis and different clinical subtypes of osteoporosis The clinical subtypes of osteoporosis primarily include postmenopausal osteoporosis, diabetic osteoporosis, glucocorticoid-induced osteoporosis, and thalassemia-related osteoporosis

Donatucci CF, Lue TF

Balazs EA

Given that self-derived signals primarily drive it, the term auto-aging is proposed to describe the accelerated aging mediated by NLRP3 in the broader population