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They are classified as ROS and reactive nitrogen species (RNS) (De Gara and Foyer, 2017)

Specific Populations Effect of Age Pediatric The valproate pharmacokinetic profile following administration of divalproex sodium extended-release tablets was characterized in a multiple-dose, non-fasting, open label, multi-center study in children and adolescents

The principal human curcumin metabolites following oral consumption are predominantly 4HC, 6HC, and glucuronide conjugates such as CG, 4HC-G, and 6HC-G (107, 108, 115)