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This especially applies to mature age patients, or those who have genetically low facial volume

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Hartmann and Kempf, 2023)

doi: 10.1016/S0006-3223(96)00365-4 60 MarxW.MoseleyG.BerkM.JackaF

That group also demonstrated a significant decrease in brain-derived neurotrophic factor, which is thought to play a key role in a variety of neuroplastic processes, including pain modulation/transduction, nociception, and hyperalgesia