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Conversely, correlation analysis showed that the metabolic correlation co-effects were higher in the serum of both LPS- and papain-induced pneumonia groups than in the control group, indicating common systemic metabolic alterations in both models (Figure 1C)

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27 An increased oxidative burden occurs in the lungs of patients with COPD, and oxidative stress may be involved in various the pathogenic processes, such as direct injury to lung cells, mucus hypersecretion, inactivation of antiproteases and enhancing lung inflammation through activation of redox-sensitive transcription factors