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The first identified agent was hydroquinone monobenzyl ether (monobenzone), which induces cell death without activating the caspase cascade or DNA fragmentation.98 Rhododendrol, another phenolic compound used in skin lightening treatments responsible for an outbreak of leukoderma in Japan, promotes cytotoxicity via a tyrosinase-dependent mechanism.99 Hair dyes have also been implicated in the appearance of leukoderma, and one of the main suspects is paraphenylenediamine

This decision is deeply personal, and its worth taking the time to explore your options, talk to your healthcare provider, and find what fits best for your goals and lifestyle

Certain chemotherapy regimens, some antibiotics if taken for long periods, and long-term use of the epilepsy drug phenytoin, carry a risk of nerve damage

M., Burrows A

In some cases, the harvest cell culture was treated with Benzonase endonuclease (Cat#: 101697, Merck KGaA, Darmstadt, Germany)