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If no improvement is observed within six months, treatment adjustment or combination therapy should be considered

When photorespiration is low, N and S assimilation is believed to be downregulated in leaves because there is an increase in nitrate reduction in roots resulting in a generally lower N/C ratio in leaves and higher xylem transport of organic N from roots to shoots 29 and furthermore, C 3 C 4 Flaveria interspecies grafts suggested that in C 4 plants (where photorespiration is suppressed), glutathione is preferentially synthesized in roots 30

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The responses to glutamine that these cell types exhibit add to the vast heterogeneity of possible metabolic schemes that cancers can adopt