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Neh 1 domain comprises of highly conserved basic region-leucine zipper (CNC-bZIP) region that dimerizes with small musculoaponeurotic fibrosarcoma (Maf) proteins and binds to ARE, a cis -acting enhancer sequence found in the promoter region of many genes encoding antioxidant and phase II detoxification enzymes or proteins

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Reversely, P53 was also reported to suppress ferroptosis in cancers by blocking dipeptidyl peptidase-4 (DPP4)-mediated lipid peroxidation in a transcription-independent manner [22], or transcriptionally upregulating the target gene CDKN1A (encoding p21) [23]

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