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It creates a chronic pro-oxidant environment that overwhelms the already-depleted GSH-based antioxidant network in diabetic patients

4613-C CLINICAL, GENETIC, AND PATHOLOGIC FEATURES, TREATMENT, AND LONG-TERM OUTCOME IN PATIENTS WITH BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS: A MULTICENTER STUDY IN JAPAN Ken Kato 1 , Shuichiro Umetsu 2 , Takao Togawa 3 , Koichi Ito 3 , Takayoshi Kawabata 4 , Teruko Arinaga-Hino 1 , Naoya Tsumura 1 , Ryosuke Yasuda 1 , Yutaro Mihara 1 , Hironori Kusano 1 , Shogo Ito 3 , Kazuo Imagawa 5 , Hisamitsu Hayashi 6 , Ayano Inui 2 , Yushiro Yamashita 1 and Tatsuki Mizuochi 1 , (1)Kurume University School of Medicine, (2)Saiseikai Yokohamashi Tobu Hospital, (3)Nagoya City University Graduate School of Medical Sciences, (4)Ishikawa Prefectural Central Hospital, (5)University of Tsukuba, (6)The University of Tokyo Background: There have been few reports of benign recurrent intrahepatic cholestasis (BRIC) from East Asia

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This process is key to DNA synthesis and methylation

However, long-term use of glucocorticoids is associated with decreased bone mineral density and increased fracture risk (96, 98), and raises the risk of infection and cardiovascular (99)