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The ERBB3 mutant protein (ERBB3 N418Q) blocked HIF-1 and NRF2 accumulation by inhibiting PI3K-AKT signaling activation, which resulted in the suppression of cancer growth and migration

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Suda M, Shimizu I, Katsuumi G, Yoshida Y, Hayashi Y, Ikegami R

New sustained-release formulations may allow quarterly dosing instead of monthly injections

Somka A, witoska M, ekanowska E (2015) Hepcidin levels are increased in patients with acute ischemic stroke: preliminary report

mTOR activation has also been targeted in these patients, although its sole action seems not to have any effect and needs to be combined with VEGF inhibitors [116]