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10.1007/s12291-015-0519-8 Indian J Clin Biochem

Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig

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In addition, chemical grafting to the 3 or 5 end can alter the tertiary structure of the aptamer which might be necessary for target binding

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