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The rationale for combining them is mechanistic complementarity (different signaling pathways, both implicated in tissue repair) and clinical anecdote in the peptide-therapy community not formal head-to-head or combination-vs-monotherapy data

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Consequently, the modification and transformation of NADs and the development of efficient, safe, and targeted delivery systems have become the primary focus of research and development on NADs

Nature 414 , 799806 (2001)

New formulations, regulatory evaluations, and continuous clinical trials will probably shape future peptide treatment